Design For Health B-Supreme 60Capsule

B-SUPREME

COENZYMATED B VITAMIN COMPLEX
60 VEGETARIAN CAPSULES

B-Supreme by Designs for Health is a comprehensive B vitamin complex formula designed to promote micronutrient status for optimal cellular function and healthy physiology. It supplies clinically useful amounts of B vitamins in their preferred coenzymated
and phosphorylated forms where possible to be used in biochemical reactions more readily and easily. B-Supreme contains the bioidentical and methylated forms of folate and vitamin B12 for superior bioavailability. Choline and trimethylglycine (TMG) are
added to help support ecient methylation for optimal genetic expression.1

HIGHLIGHTS
• Formulated with bioidentical and coenzymated forms of B vitamins for enhanced absorption and bioavailability
• Features the bioactive form of folate, as Quatrefolic® [6S]-5-methyltetrahydrofolate (MTHF), and vitamin B12, as MecobalActive® methylcobalamin
• Choline and TMG added to support methylation pathways
• Vegetable capsule; suitable for vegetarians and vegans
B vitamins are a family of eight water-soluble micronutrients that are needed in small amounts by the body. B vitamins fall into two main categories: (1) those involved in the transfer of single-carbon atoms (i.e., one-carbon metabolism), and (2) those involved in the enzymatic reactions related to energy production and redox status.2 High-risk populations for B vitamin deficiencies include vegans and vegetarians, alcoholics, patients with congestive heart failure, obesity, and diabetes, the elderly, and individuals who have had bariatric surgery.3-5 Supplementation with B complex vitamins has been shown to reduce homocysteine (Hcy) levels (an inflammatory marker in cardiovascular, metabolic, and neurological conditions), slow the rate of cognitive decline, and exhibit
analgesic properties by activating the nitric oxide/cyclic guanosine monophosphate (cGMP) pathway.6-10
The levels of vitamins B2, B6, B12, and folate found in B-Supreme are adequate for maintaining healthy Hcy levels for a large section of the population, but not for those with single nucleotide polymorphisms (SNP) in the Hcy metabolic pathways and/or folate
receptor activity.11-13 The GenomicInsight™ report by Diagnostic Solutions Laboratory identifies which nutrients are required in higher doses to normalize Hcy within the body. This test is relevant to both the maternal and paternal genomic profiles, considering that the ospring inherit a combination of both.14

Ingredient Highlights
Thiamin (vitamin B1) is an essential nutrient coenzyme for cellular energy production (ATP), making it a critical vitamin for normal growth and development, cardiac function, and brain and nervous system health. B1 plays a major neuromodulatory role in
acetylcholine neurotransmission and is crucial to the structure and function of neurons and neuroglia.5 Deficiency is often a result of gastrointestinal malabsorption caused by heavy alcohol dependence.5 Animal studies showed that chronic alcohol application in
conjunction with severe thiamine deficiency resulted in profound changes in neuroimmune genes, with a moderate-to-severe increase of pro-inflammatory cytokines within the thalamus, hippocampus, and frontal cortex.15
In healthy subjects, there was a linear dose response in whole blood and plasma levels following single oral doses, ranging from 100mg to 1,500 mg of thiamine HCl, which corresponds to nearly 1,000 times the RDA.5,16 Compared to a placebo, 50 mg of oral thiamine for 2 months led to improvements in mood and attention in 120 healthy, young females.5,17
Vitamin B2 (riboflavin and riboflavin-5-phosphate-derived coenzymes), flavin mononucleotide and flavin dinucleotide are crucial rate-limiting factors in many biochemical reactions, including heme protein synthesis and the synthesis, conversion, and recycling of niacin, B6, and folate. They are also essential cofactors in the redox cycle of glutathione, the metabolism of brain lipids and essential