XYMOGEN®-Methylcobalamin 60 Tablets

Methylation Methylcobalamin is required for the function of methionine synthase the folate-dependent enzyme required for the synthesis of methionine, an amino acid, from homocysteine. Methionine, in turn, is required for the synthesis of S-adenosylmethionine (SAMe), a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA and RNA. As an example of its importance in homocysteine metabolism, one study showed that the addition of B12 to a folate regimen had a greater impact (7%) on homocysteine than did folate alone.