SLOTH MEDICAL (R)-African Aloe, 60 vcaps

Aloe Ferox vs Aloe Vera

Aloe Ferox gel differs substantially from that of Aloe Vera. A report indicated that 14 distinct polysaccharide entities were distinguished from the gel of A. ferox from Aloe Vera. In addition, nitrogen analysis of leaf extracts revealed that the amino acid asparagine was the most abundant, followed by glutamine, alanine and histidine.

Aloe Ferox as a laxative

The constipation is the most common gastrointestinal disorder and it is considered a risk factor for colorectal cancer. Since it is not the most comfortable topic to talk about, it is frequently overlooked and left unaddressed.

Cape Aloe is widely used for its potent laxative and cathartic effects which are attributed to anthraquinones and in particular to aloe emodin.

The anthrone- C- glycosides (aloin A and B) are considered stable in the stomach which protects them from breakdown in the intestine before they reach their site of action in the colon and rectum.

Once they have reached the large intestine the glycosides behave like prodrugs, liberating (through bacterial breakdown, particularly Eucobacterium sp) the aglycones - Aloe emodin, that act as the laxative trough to several mechanisms¹:

Aloe-emodin possibly exerts its action by disturbing the equilibrium between the absorption of water from the intestinal lumen via an active sodium transport, and the secretion of water into the lumen by a prostaglandin-dependent mechanism (increased water volume into the intestine). This way, aloe emodin stimulates colonic motility without stimulating colonic muscle directly like other stimulant laxatives.

Augment the propulsion and accelerate colonic transit. Consequently, this reduces fluid absorption from fecal mass. This water content makes stool softer and easier to pass.

It increases paracellular permeability across the colonic mucosa by inhibition of (Na++K+)-ATPase, which again results in an increase in the water content in the large intestine. These help the colon retain more water, increasing the frequency of bowel movements and exhibiting mechanism of osmotic laxative.

This is a very unique natural constipation relief product with multiple mechanisms of actions. By stimulating the bowel movement indirectly, it is considered non addictive and suitable for occasional constipation.

Dose

It is recommended to start with one capsule with water, before bedtime. Patient should have bowel movement in the morning.

It is not uncommon to have several BM at the beginning of treatment, due to past irregularity.

Max Dose

The dose can be increased up to maximum 3 capsules, taken as a single dose before bedtime.

These are very rare cases that require more than one capsule for a treatment.

PRECAUTIONS:

Due to lack of studies in special populations, it is not recommended to take Cape Aloe capsules if pregnant, lactating or in children.

SIDE EFFECTS:

Possible allergic reaction to aloe compounds in history of specific allergies: it is not recommended to use if diarrhea occurs, the treatment should be discontinued.