Thorne Melaton-3 60 Capsules (ShortDated Apr 2025)

Melatonin, the primary hormone of the pineal gland, is a powerful "chronobiotic" that helps maintain the body's normal circadian rhythms.* In individuals who have difficulty sleeping or who have altered circadian rhythms because of jet lag or night shift work, melatonin supplementation promotes the resynchronization of this cycle.* Supplementation can also benefit those whose difficulty sleeping is caused by the aging-related decrease in the body's ability to synthesize melatonin from the amino acid tryptophan.* Research indicates melatonin exerts its sleep-promoting efficacy by decreasing the amount of time needed to fall asleep, by promoting the ability to stay asleep, and by enhancing the depth of sleep.*

Melatonin administration from 0.3 mg to 5.0 mg has been shown to exert a sedative-like effect.* When supplemented prior to the onset of the body's normal melatonin secretion, even a low amount of melatonin can promote sleep.* Melatonin apparently enhances the effect of gamma-aminobutyric acid (GABA) via direct interaction with GABA receptors, thus resulting in relaxation.* Thorne's Melaton-3 supplies three mg of melatonin in each capsule, and Melaton-5 supplies 5 mg per capsule and is used when a higher amount of melatonin is desired. Melatonin also has significant antioxidant activity.* Adequate melatonin levels have been reported to be a positive factor in cardiovascular, neuroendocrine, GI, and bone health.* Recommended Use or Purpose: Helps increase total sleep time (aspect of sleep quality) in people suffering from sleep restriction or altered sleep schedule, e.g., shift work and jet lag. Helps reduce the time it takes to fall asleep (sleep onset latency aspect of sleep quality) in people with delayed sleep-phase syndrome. Helps reset the body’s sleep-wake cycle (aspect of the circadian rhythm).

Recommended Dose (Adults): Take 1-2 capsules daily at or before bedtime or as recommended by a health-care practitioner. Consult a health-care practitioner for use beyond 4 weeks. Risk Information: Consult a health-care practitioner prior to use if you have a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension or if you are taking blood pressure or sedative/hypnotic medications. Consult a health-care practitioner if symptoms persist continuously for more than 4 weeks (chronic insomnia). Do not use if you are taking immunosuppressive drugs. Do not drive or use machinery for 5 hours after taking melatonin. Do not use if you are pregnant or breastfeeding.

Keep out of reach of children. Do not use if security seal inside the cap is broken. Store tightly sealed in a cool, dry place.