Provita - Ptero Gene - 60 Capsules

Provita - Ptero Gene - 60 Capsules

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Anti-aging antioxidants - Provides unique antioxidants

Benefits

Provides unique antioxidants

 Increases antioxidant bioavailability

 Protects against oxidative stress

 Activates Calorie Restriction Factor (CRF)

 

There are many species of antioxidants, but not all are created equal. Although Pterostilbene is a phenol that is chemically related to Resveratrol it differs by increased bioavailability and and a well-defined activity in the body.

Pterostilbene is isolated from the stem heartwood of Pterocarpus marsupium while resveratrol is extracted from the root of Reynoutria japonica (synonyms Fallopia japonica and Polygonum cuspidatum). Although they are both antioxidants, resveratrol and pterostilbene complement each other by the outcomes of their specific antioxidant effects.

  • The antioxidant effect of resveratrol provides for activation of calorie restriction mimetic and telomere maintenance factors with main outcomes being cardiovascular and anti-aging effects.
  • Pterostilbene acts as an antioxidant by activating AMPK (AMP-activated protein kinase) that regulates energy metabolism, and by activating Sirtuin 1. Obesity and aging diminish Sirtuin 1 (1, 2). Sirtuin 1 is NAD dependent, therefore increasing NAD+ levels can enhance the effect of pterostilbene.

SIRT1 is one of the most important transcriptional factors that drives many cellular activities, like energy metabolism, cell survival, DNA stability, inflammation, and circadian rhythms (3).

The added Quercetin is itself an antioxidant complementing Resveratrol and Pterostilbene. At the same time when Quercetin and Medium Chain Triglycerides (MCT) are associated with Resveratrol and Pterostilbene, the overall bioavailability of these antioxidants can be potentiated. Added specialized Piperine extract – Bioperine® (Sabinsa Corp.) – helps to increase resveratrol delivery (4).

 

References:

  1. Pterostilbene Monograph, Alternative Medicine Review, Volume 15, Number 2
  2. Yi-Rong Li et al., Effect of resveratrol and pterostilbene on aging and longevity, International Union of Biochemistry and Molecular Biology, Volume 44, Number 1, January/February 2018, Pages 69–82
  3. Alessandra Stacchiotti et al. – Resveratrol snd Sirt1 Activators for the treatment of Aging and Age-related diseases, http://dx.doi.org/10.5772/intechopen.78977-2018, Chapter 6
  4. James M. Smoliga and Otis Blanchard, Enhancing the Delivery of Resveratrol in Humans, Molecules 2014, 19, 17154-17172

Did you know

In general, Sirtuins help regulate your cellular health, but they can only function in the presence of NAD+. Sirtuin 1 is particuarly important as it is a protein encoded by the SIRT1 longevity gene.